No completed MLB games for October 4, 2021.
American League
| East | W | L | Pct | GB | Strk |
|---|
| Rays | 76 | 50 | .603 | - | W1 |
| Yankees | 71 | 55 | .563 | 5 | W3 |
| Red Sox | 68 | 59 | .535 | 8.5 | L1 |
| Blue Jays | 62 | 66 | .484 | 15 | L1 |
| Orioles | 61 | 66 | .480 | 15.5 | L3 |
| Central | W | L | Pct | GB | Strk |
|---|
| White Sox | 66 | 60 | .524 | - | W1 |
| Twins | 63 | 65 | .492 | 4 | W3 |
| Guardians | 61 | 66 | .480 | 5.5 | L1 |
| Tigers | 61 | 66 | .480 | 5.5 | L2 |
| Royals | 54 | 74 | .422 | 13 | W4 |
| West | W | L | Pct | GB | Strk |
|---|
| Astros | 64 | 63 | .504 | - | W1 |
| Rangers | 62 | 65 | .488 | 2 | L1 |
| Mariners | 60 | 67 | .472 | 4 | W1 |
| Angels | 50 | 77 | .394 | 14 | L1 |
| Athletics | 49 | 78 | .386 | 15 | L3 |
National League
| East | W | L | Pct | GB | Strk |
|---|
| Braves | 74 | 53 | .583 | - | L3 |
| Phillies | 70 | 58 | .547 | 4.5 | W6 |
| Marlins | 64 | 64 | .500 | 10.5 | L3 |
| Nationals | 61 | 67 | .477 | 13.5 | W1 |
| Mets | 58 | 70 | .453 | 16.5 | W1 |
| Central | W | L | Pct | GB | Strk |
|---|
| Brewers | 78 | 49 | .614 | - | L1 |
| Cubs | 74 | 54 | .578 | 4.5 | L1 |
| Cardinals | 65 | 63 | .508 | 13.5 | L1 |
| Pirates | 63 | 66 | .488 | 16 | W2 |
| Reds | 61 | 66 | .480 | 17 | W1 |
| West | W | L | Pct | GB | Strk |
|---|
| Dodgers | 77 | 51 | .602 | - | W3 |
| Padres | 68 | 60 | .531 | 9 | L1 |
| Diamondbacks | 67 | 61 | .523 | 10 | W1 |
| Giants | 52 | 74 | .413 | 24 | W1 |
| Rockies | 50 | 77 | .394 | 26.5 | L3 |
American League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Yankees | 71 | 55 | .563 | +9 | W3 |
| Red Sox | 68 | 59 | .535 | +5.5 | L1 |
| Twins | 63 | 65 | .492 | - | W3 |
| Rangers | 62 | 65 | .488 | 0.5 | L1 |
| Blue Jays | 62 | 66 | .484 | 1 | L1 |
| Guardians | 61 | 66 | .480 | 1.5 | L1 |
| Orioles | 61 | 66 | .480 | 1.5 | L3 |
| Tigers | 61 | 66 | .480 | 1.5 | L2 |
| Mariners | 60 | 67 | .472 | 2.5 | W1 |
| Royals | 54 | 74 | .422 | 9 | W4 |
| Angels | 50 | 77 | .394 | 12.5 | L1 |
| Athletics | 49 | 78 | .386 | 13.5 | L3 |
National League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Cubs | 74 | 54 | .578 | +6 | L1 |
| Phillies | 70 | 58 | .547 | +2 | W6 |
| Padres | 68 | 60 | .531 | - | L1 |
| Diamondbacks | 67 | 61 | .523 | 1 | W1 |
| Cardinals | 65 | 63 | .508 | 3 | L1 |
| Marlins | 64 | 64 | .500 | 4 | L3 |
| Pirates | 63 | 66 | .488 | 5.5 | W2 |
| Reds | 61 | 66 | .480 | 6.5 | W1 |
| Nationals | 61 | 67 | .477 | 7 | W1 |
| Mets | 58 | 70 | .453 | 10 | W1 |
| Giants | 52 | 74 | .413 | 15 | W1 |
| Rockies | 50 | 77 | .394 | 17.5 | L3 |