No completed MLB games for December 22, 2021.
American League
| East | W | L | Pct | GB | Strk |
|---|
| Rays | 75 | 49 | .605 | - | W1 |
| Yankees | 69 | 55 | .556 | 6 | W1 |
| Red Sox | 66 | 58 | .532 | 9 | L1 |
| Orioles | 61 | 64 | .488 | 14.5 | L1 |
| Blue Jays | 61 | 65 | .484 | 15 | L1 |
| Central | W | L | Pct | GB | Strk |
|---|
| White Sox | 65 | 58 | .528 | - | W3 |
| Tigers | 60 | 64 | .484 | 5.5 | L3 |
| Twins | 60 | 65 | .480 | 6 | L3 |
| Guardians | 60 | 65 | .480 | 6 | L1 |
| Royals | 51 | 74 | .408 | 15 | W1 |
| West | W | L | Pct | GB | Strk |
|---|
| Astros | 63 | 62 | .504 | - | L2 |
| Rangers | 61 | 64 | .488 | 2 | L1 |
| Mariners | 59 | 66 | .472 | 4 | W2 |
| Athletics | 49 | 75 | .395 | 13.5 | W1 |
| Angels | 49 | 76 | .392 | 14 | L1 |
National League
| East | W | L | Pct | GB | Strk |
|---|
| Braves | 74 | 50 | .597 | - | W1 |
| Phillies | 67 | 58 | .536 | 7.5 | W3 |
| Marlins | 64 | 61 | .512 | 10.5 | W2 |
| Nationals | 60 | 66 | .476 | 15 | L3 |
| Mets | 56 | 69 | .448 | 18.5 | W3 |
| Central | W | L | Pct | GB | Strk |
|---|
| Brewers | 77 | 48 | .616 | - | W2 |
| Cubs | 72 | 53 | .576 | 5 | L2 |
| Cardinals | 64 | 61 | .512 | 13 | W3 |
| Pirates | 61 | 65 | .484 | 16.5 | W1 |
| Reds | 59 | 65 | .476 | 17.5 | L3 |
| West | W | L | Pct | GB | Strk |
|---|
| Dodgers | 74 | 51 | .592 | - | L2 |
| Padres | 67 | 58 | .536 | 7 | W1 |
| Diamondbacks | 66 | 59 | .528 | 8 | L1 |
| Giants | 51 | 73 | .411 | 22.5 | L1 |
| Rockies | 50 | 74 | .403 | 23.5 | W1 |
American League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Yankees | 69 | 55 | .556 | +8.5 | W1 |
| Red Sox | 66 | 58 | .532 | +5.5 | L1 |
| Rangers | 61 | 64 | .488 | - | L1 |
| Orioles | 61 | 64 | .488 | - | L1 |
| Blue Jays | 61 | 65 | .484 | 0.5 | L1 |
| Tigers | 60 | 64 | .484 | 0.5 | L3 |
| Twins | 60 | 65 | .480 | 1 | L3 |
| Guardians | 60 | 65 | .480 | 1 | L1 |
| Mariners | 59 | 66 | .472 | 2 | W2 |
| Royals | 51 | 74 | .408 | 10 | W1 |
| Athletics | 49 | 75 | .395 | 11.5 | W1 |
| Angels | 49 | 76 | .392 | 12 | L1 |
National League
| Wild Card | W | L | Pct | WCGB | Strk |
|---|
| Cubs | 72 | 53 | .576 | +5 | L2 |
| Phillies | 67 | 58 | .536 | - | W3 |
| Padres | 67 | 58 | .536 | - | W1 |
| Diamondbacks | 66 | 59 | .528 | 1 | L1 |
| Marlins | 64 | 61 | .512 | 3 | W2 |
| Cardinals | 64 | 61 | .512 | 3 | W3 |
| Pirates | 61 | 65 | .484 | 6.5 | W1 |
| Nationals | 60 | 66 | .476 | 7.5 | L3 |
| Reds | 59 | 65 | .476 | 7.5 | L3 |
| Mets | 56 | 69 | .448 | 11 | W3 |
| Giants | 51 | 73 | .411 | 15.5 | L1 |
| Rockies | 50 | 74 | .403 | 16.5 | W1 |